It's in the name.
Butyrate takes its name from butter, where it was first found. Your own gut bacteria make it too, by fermenting the fiber you eat. BUTTYR is named for it.
Advanced microbiome support · No.01
Supports the microbiome for whole-body wellness.* Butyrate, restored beautifully.
The short-chain fatty acid
Your gut bacteria make it from fiber. Butter is where it was first found. Most people have never heard of it. BUTTYR is built around it.
Every dose, in plain sight
Tributyrin and five gut-lining actives, each at a meaningful dose, every one printed on the label where you can read it.
Port Rx
Founded by Natalie Bronco, who read every label so you don't have to.
The honest comparison
Natalie spent her nights reading competitor labels on each brand's own website. Here is what she found, in two lines.
A proprietary blend, a promising ingredient at a dose you can't find, and a tub you keep hidden in the cabinet.
Tributyrin plus five gut-lining actives, every dose printed on the label, in amber glass you'll want to leave out.
The science, simply
Ask most people what butyrate is and they will tell you they don't know. So we teach first and sell second.
Butyrate takes its name from butter, where it was first found. Your own gut bacteria make it too, by fermenting the fiber you eat. BUTTYR is named for it.
Butyrate is the main source of energy for the cells that line your colon. A well-fed lining supports healthy gut barrier function.*
Magnesium comes as glycinate or citrate. Butyrate comes in forms too. BUTTYR is built around tributyrin: three butyrate units bound to one glycerol backbone, released as it is digested.
TRIBUTYRIN
The math, in plain sight
1295mg
of named, dosed actives in every four-capsule serving. Nothing hidden in a blend.
Per serving of four capsules, from our manufacturer's July 2026 label specification. Bars are drawn to scale. Final label doses are confirmed before the first batch ships.
The stripe is the system
Butter belongs to BUTTYR.
The formula
Six actives, nothing decorative. A butyrate core, the botanicals and minerals that care for the lining, and a hardy probiotic. Every dose printed in plain sight.
Butyrate in its triglyceride form: three butyrate units on one glycerol backbone. The reason BUTTYR exists.
A resin extract from the mastic tree, a traditional botanical for digestive comfort.*
Quercetin, a plant flavonoid, in a phospholipid form.
Licorice root with the glycyrrhizin removed, a traditional ingredient for the stomach lining.*
Zinc bound to L-carnosine, chosen to support the gut lining.*
A spore-forming probiotic, sturdy enough to live in a capsule. Two billion CFU per serving.
From our manufacturer's July 2026 label specification. Final label copy is confirmed before the first batch ships.
The object
Most supplements live in a cabinet because they look like they belong there. BUTTYR was designed to earn the counter: quiet, warm, and honest down to the label. The easier it is to see, the easier it is to keep.
Before BUTTYR was a brand, it was the gut supplements Natalie actually took, read closely, and compared.
One word kept coming up in everything she read. Butyrate. It was all over the research she saved, and almost nowhere in the conversation. Ask most people what it is and they will tell you they don't know.
So she started building. Much of the work happened late at night. She pulled up competing products on the brands' own websites and checked the doses against the labels herself, after an AI-built comparison table got one wrong.
“We want to keep all the dosages of each ingredient at a meaningful amount.”
Natalie, on the formula · June 2026
That one sentence cost her the easy version of this business. They had hoped for three capsules a day. Keeping every dose meaningful took four, so four it is. It also meant a fully custom formula, and she knew going in it would be “very expensive.” She chose it anyway. She had built an early version with a practitioner she trusts, then revised it herself and went looking for more opinions. But the spec was hers. In her words: “I am the one suggesting.”
Then she gave it a body worth keeping. Natalie led the brand: amber glass to keep light out, a clinical voice, a label where every number can be read. She wanted it, in her words, “somewhat pharmaceutical,” never playful. When the renders came back gold, she sent them back. Not gold, she said. Butter yellow.
BUTTYR is the supplement she went looking for and couldn't find. Butyrate at its core, six actives in plain sight, beautiful enough to leave on the counter.
The plan, in one message: a brand called Port Rx, a first product called BUTTYR, and a standard of clinical simplicity.
Late 2025
The ritual
No powders to stir. No gummies to ration. Four capsules, once a day. That is the whole routine.

Pick the moment you never skip, morning or night. A glass of water is all you need.
No loading phase and no breaks to plan around. BUTTYR is built for consistency.
Restoration takes a little time. Give it a full jar, thirty days of consistent use, before you judge it.
A note from Port Rx
Restoration takes a little time. We're glad you started.
The founding list
The first run of BUTTYR will be small. The founding list is how you get it first, and it costs you nothing but an email address.
One email address
Join the founding list
No spam and no false urgency. First access, founding pricing, and the occasional field note on the science.
Good questions
If your question isn't here, write to us. A person reads every message.
A daily microbiome supplement built around tributyrin, a form of butyrate: the short-chain fatty acid your gut bacteria make from fiber to fuel the gut lining. Six actives, four capsules a day, every dose printed on the label.
Butyrate is a short-chain fatty acid your gut bacteria make from fiber, and the main energy source for the cells lining your colon. Tributyrin carries three butyrate units on one glycerol backbone and releases them as it is digested. It is the core of the formula, at 300 mg per serving, alongside five gut-lining actives.
Four capsules, once a day. No cycling and no loading phase. One jar holds 120 capsules, a 30-day supply.
Honestly, it is gradual, and everyone is different. Give it a full jar of consistent daily use before you judge it. Restoration takes a little time.
BUTTYR is a dietary supplement for healthy adults. If you are pregnant, nursing, taking medication or managing a health condition, talk with your healthcare provider first.
Because light is not your formula's friend. Amber glass protects what's inside, and it is beautiful enough to leave out, which makes the habit easier to keep.
The first batch is in the works. The founding list hears first, with first access and founding pricing before BUTTYR opens to everyone.
Science, restored beautifully
BUTTYR
Butyrate at its core. Every dose in plain sight. A founder who read every label so you don't have to.